Chondrocyte homeostasis

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August undefined, 2024

WebMay 28, 2024 · The alteration of intracellular calcium homeostasis is a major upstream contributor to the activation of caspase-9, which may be a stress-induced signalling pathway for articular chondrocyte death. Furthermore, mechanical stimulation has been found to alter calcium homeostasis in most cell types [80, 81], as well as in OA chondrocytes … WebJun 26, 2024 · Joint health appears to depend on chondrocyte homeostasis, but a full understanding of the process has been slow to come into focus. A growing body of …

Inhibition of TRADD ameliorates chondrocyte necroptosis …

WebJan 13, 2024 · These findings offer further evidence that A2AR may be an excellent target for promoting chondrocyte and cartilage homeostasis. Autophagy, a homeostatic pathway upregulated during cellular stress ... WebChondrocyte mechanotransduction appears to involve the integration and transduction of multiple biophysical signals that arise from joint loading, including direct matrix, cellular, and nuclear strain, hydrostatic pressurization, fluid shear, and changes in tissue osmolarity ().Ion channels, integrin signaling, and the primary cilia have all been implicated in transducing … aussi vrai

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WebApr 14, 2024 · Upregulation of β-catenin protein levels in patients with disc degeneration and facet joint osteoarthritis. To evaluate the role of β-catenin signaling in maintaining the homeostasis of the FSU ... WebOur lab has shown CGS21680 (CGS, 1µM) activation of adenosine A2AR leads to chondrocyte homeostasis. We have demonstrated in vitro and in vivo activation of … WebMetalloproteinase with thrombus motifs, matrix metalloproteinase (MMPs), and Type II collagen are key proteins that induce ECM degradation of articular cartilage and play a key role in maintaining chondrocyte homeostasis . Numerous cytokines and non-coding RNA can induce OA by stimulating ECM degradation of articular cartilage. lauren sinon

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Adenosine A2A receptor signaling promotes FoxO associated

WebThe purpose of this study was two-fold: to assess whether mechanical stimulation modulates β-catenin signalling and catabolic gene expression in articular … WebThis clinically relevant cluster was predicted to be the main chondrocyte cluster responsible for maintaining cellular homeostasis and anti-senescence. Specifically, we uncovered a set of the key leading-edge proteins of cluster 3 by validating the robustness of the above results using another human chondrocyte single-cell RNA-sequencing data ... lauren siy-keaneWebThis review aims to summarize the role of mitochondria in chondrocytes under the physiological and pathological changes from ATP generation, calcium homeostasis, … aussois meteo

"WebMar 10, 2024 · Moreover, miR-760 was confirmed to control chondrocyte matrix homeostasis by targeting HBEGF, and the overexpression of HBEGF partially reversed the effects of miR-760 mimic treatment on the degradation of the cartilage ECM. When OA model mice were administered an intra-articular knee injection of an adenoviral vector … " - Chondrocyte homeostasis

Chondrocyte homeostasis

Histology, Chondrocytes - StatPearls - NCBI Bookshelf

WebJul 1, 2024 · Then, the influence of TDP-43 on chondrocyte homeostasis was investigated by overexpressing or silencing TDP-43 in human chondrocytes under H 2 O 2 treatment. As a result, on both the protein and RNA levels, there was an obvious negative correlation between TDP-43 and chondrocyte catabolism. WebMay 5, 2024 · New research is revealing essential roles for Sox9 in postnatal cartilage homeostasis and in preventing post-traumatic osteoarthritis, along with new …

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WebMar 23, 2016 · Overexpression of miR-365 induces chondrocyte differentiation marker Ihh and MMP13 and exacerbates the IL-1 induced catabolic effects in chondrocytes. We further show HDAC4 is a direct target of miR-365, which mediates mechanical stress and inflammation in OA pathogenesis, thereby leading to accelerated cartilage destruction.

WebJan 15, 2024 · SDF-1α, the most common isoform of stromal cell-derived factor 1, has shown vital effects in regulating chondrocyte proliferation, maturation, and chondrogenesis. Autophagy is a highly conserved biological process to help chondrocytes survive in harsh environments. However, the effect of SDF-1α on chondrocyte autophagy is still … WebMar 31, 2024 · Inhibition of TRADD can activate autophagy to maintain cellular homeostasis . In our results, ICCB-19 treatment could promote autophagic level of …

WebOct 30, 2015 · Abstract. Apoptosis is a highly-regulated, active process of cell death involved in development, homeostasis and aging. Dysregulation of apoptosis leads to pathological states, such as cancer, developmental anomalies and degenerative diseases. Osteoarthritis (OA), the most common chronic joint disease in the elderly population, is … WebMay 28, 2024 · Cartilage homeostasis involves the regulation of multiple growth factors and the transduction of cellular signals. It is a very complicated process that …

WebMar 31, 2024 · Inhibition of TRADD can activate autophagy to maintain cellular homeostasis . In our results, ICCB-19 treatment could promote autophagic level of chondrocyte even without TNF-α exposure (Fig. (Fig.7). 7). It has been reported that increased autophagic level could attenuate age-related diseases including OA [37, 43, …

WebAug 26, 2024 · Mechanical cues can promote chondrocyte homeostasis or hypertrophy and mineralization, depending potentially on the timing of load application. Here, we tested the effects of chondrogenic priming duration on the response of engineered human cartilage constructs to dynamic mechanical compression. We cultured human bone marrow … lauren siskWebMay 15, 2024 · The Notch and NF-κB signalling pathways regulate articular chondrocyte homeostasis and OA development in various ways. Comprehensive understanding of the molecular networks including articular chondrocyte differentiation is needed for further elucidation of OA pathogenesis. aussois meteo eteWebMar 11, 2024 · Our findings suggest strategies for restoring chondrocyte homeostasis in osteoarthritis. A dysfunctional TRPV4–GSK3β pathway in osteoarthritic chondrocytes renders the cells unable to respond ... lauren skaar photosWebAst inhibited cartilage endplate calcification, modulated chondrocytes, and ECM homeostasis, and suppressed chondrocyte ferroptosis and apoptosis by activating the Nrf-2/HO-1 signaling pathway. Meanwhile, Ast repressed oxidative stress and inflammation by regulating NF-κB signaling pathway and autophagic program. aussoisWebMay 25, 2024 · MFG-E8 restores chondrocyte homeostasis in OA. Histomorphometric analysis revealed a progressive loss of articular cartilage in mice in a time-dependent … lauren simpkins audiologistWebMar 23, 2024 · This clinically relevant cluster was predicted to be the main chondrocyte cluster responsible for maintaining cellular homeostasis and anti-senescence. Specifically, we uncovered a set of the key leading-edge proteins of cluster 3 by validating the robustness of the above results using another human chondrocyte single-cell RNA … lauren simmons cnbc make itWebOct 30, 2015 · The role of subchondral bone in the maintenance of proper cartilage matrix has been suggested as well, and it has been proposed that both articular cartilage and … ausstattungspolitik