WebThe murine GBP2 gene is not just highly activated by the interferon-gamma during macrophages activation but also by the stimulation of Toll-like receptors, Tumor necrosis factor (TNF) and Interleukin 1 beta. ... GBP2 is considered as a control factor for the proliferation and spreading in the tumor cell. The high expression of GBP2 is ... WebMar 4, 2024 · Human GBP2 is a directly down-regulated target of miR-433 in leukemia (Lin et al., 2013), and several mouse GBPs including Gbp2, Gbp3, Gbp4, Gbp5, Gbp6, Gbp8, …
Guanylate-binding protein 2 orchestrates innate immune …
WebBoth GBP2 and GBP5 associate with bacteria GBP1-dependently but only GBP2 incorporates in the microcapsule. Recombinant Alexa Fluor 488-labeled GBP1, ... D. Fisch et al., Human GBP1 is a microbe-specific gatekeeper of macrophage apoptosis and pyroptosis. EMBO J. 38, e100926 (2024). Crossref. PubMed. WebGBP2 Antibodies. Antibodies that detect GBP2 can be used in several scientific applications, including Immunohistochemistry, Western Blot, Immunocytochemistry, Flow … key peele slave auction
GBP2 - Wikipedia
WebApr 16, 2024 · The cytokine CCL5 is elevated following Her2 downregulation and remains high in residual tumors. CCL5 promotes tumor recurrence by recruiting CCR5-expressing macrophages, which may contribute to collagen deposition in residual tumors. Blocking this TNFα-CCL5-macrophage axis may be efficacious in preventing breast cancer recurrence. WebThe access to or release of microbial ligands in infected macrophages required GBP1, which therefore acts a gatekeeper of microbe-induced cell death. GBP1 joins GBP2 and … WebComplete ablation of GBP2 and 5 by CRISPR in THP-1 macrophages, in contrast to downregulation by siRNA, showed that these two GBPs are in fact not able to kill Tg via control of the vacuole/cell ratio (Figs 1D and 2C). Using HRMAn we further assessed the overall effect of GBP1, 2 and 5 on the total parasite load per cell (Fig. 2D). island catering services