Tfrc knockin
Web9 Apr 2024 · TFRC upregulation promotes ferroptosis in CVB3 infection via nucleus recruitment of Sp1. Iron metabolism protein transferrin receptor 1 involves in cervical cancer progression by affecting gene expression and alternative splicing in HeLa cells. Host receptor-targeted therapeutic approach to counter pathogenic New World … Web13 May 2024 · Transferrin receptor (TFRC) is the major mediator for iron entry into a cell. Under excessive iron conditions, TFRC is expected to be downregulated via the iron regulatory protein and the iron-responsive element machinery to …
Tfrc knockin
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Web28 Mar 2024 · This is the website of the Time For Real Change in UNISON campaign. UNISON is crying out for real change. We are rank and file UNISON activists determined to make our union democratic, transparent and successful - a fighting union that delivers for its members. Find out more about us and get involved with our campaign on our website. Web9 Apr 2024 · Summary. This gene encodes a cell surface receptor necessary for cellular iron uptake by the process of receptor-mediated endocytosis. This receptor is required for …
Web17 Jan 2024 · Transferrin receptor (TFRC), which was overexpressed in cervical cancer and involved in the HIF-1 pathway, was associated with advanced clinical pathologic characteristics. It was also an... Web27 Oct 2024 · Results presented Fig. 5c demonstrate that TFR1 (CD71) and iron regulatory protein 1 (IRP1) are downregulated in the presence of HSA-heme in Jurkat T cells, …
Web23 Jan 2024 · To obtain TFRC knockdown cells, short hairpin RNA (shRNA) transfection method was used to transfect it into HeLa cells. The TFRC -shRNA sequence (5ʹ-GCT GGT CAG TTC GTG ATT AAA-3ʹ) was introduced into pGFP-B-RS vectors (Origene, Peking, China), which were digested by BamH I and Hind III enzymes. Web19 May 2024 · MYCN is a regulator of GPX4-dependent ferroptosis. To study MYCN-dependent cellular processes in NB, we examined a collection of 147 genes essential for the survival of MYCN-amplified NB cells 17 ...
Web17 Jan 2024 · Transferrin receptor (TFRC), which was overexpressed in cervical cancer and involved in the HIF-1 pathway, was associated with advanced clinical pathologic …
Web5 Nov 2024 · The IREB2 gene encodes an iron-responsive element-binding protein (IRP) that regulates the expression of proteins involved in iron metabolism by binding to iron-responsive elements in the mRNAs of target genes, which include the transferrin receptor (TFRC; 190010) as well as the heavy and light ferritin chains (FTH1, 134770 and FTL, … bryce harper opt outWeb11 Jul 2024 · TFRC encodes the transferrin receptor protein 1 (TFR1, UniProt-P02786) in human, which controls the level of intracellular iron levels. TFR1 imports iron from the … bryce harper pc wallpaperWebTransferrin receptor 1. Transferrin receptor protein 1 ( TfR1 ), also known as C luster of D ifferentiation 71 ( CD71 ), is a protein that in humans is encoded by the TFRC gene. [5] [6] … bryce harper pantsWeb23 Jan 2024 · Background Transferrin receptor 1 (TfR1), encoded by TFRC, is a key regulator of iron homeostasis and plays important roles in many diseases, including cancers. … bryce harper payrollWeb8 Jun 2024 · Background and Aims: Iron deficiency (ID) is a frequent extra-intestinal manifestation in patients with Inflammatory Bowel Disease (IBD), who often do not respond to iron supplementation. Iron is a cofactor for hydroxylases that suppress the hypoxia-inducible factor-1α (HIF1α), a transcription factor regulating iron homeostasis. We … bryce harper outfield gloveWeb5 Jul 2024 · The Tfrc AKO mice were also protected from obesity induced by a high-fat diet (HFD). Compared with control mice, Tfrc AKO mice had increased iron storage in the liver and a lower adipose mass ... bryce harper pearl necklaceWeb24 Jan 2024 · Transferrin receptor 1 (Tfr1) mediates uptake of circulating transferrin-bound iron to developing erythroid cells and other cell types. Its critical physiological function is highlighted by the embryonic lethal phenotype of Tfr1-knockout (Tfrc -/-) mice and the pathologies of several tissue-specific knockouts. bryce harper phanatic shoes